Article

Synthesis of mRNA lipid nanoparticles for engineering GD2 CAR T and CAR NK cells against neuroblastoma

2025-12-17

Abstract excerpt

<h4> Abstract </h4> Engineering T and natural killer (NK) cells with chimeric antigen receptors (CAR) creates effective adoptive cell transfer therapies for cancer treatment. However, using viral transduction as a primary genetic modification method adds regulatory burdens and is expensive to produce at scale. Delivering mRNA encoding CAR via lipid nanoparticles (LNPs) has been explored as a potent non-viral met...

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Literature Corpus work: ef9bfaec-041d-52da-91a4-edb041e26049
DOI: 10.64898/2025.12.15.692195

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