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A lipid nanoparticle platform for high yield CRISPR-targeted homology directed repair enables fully non-viral CAR T cell generation

2026-08-05

Abstract excerpt

CRISPR-mediated homology directed repair (HDR) enables targeted CAR integration with improved fitness and therapeutic potential of CAR T cells. However, current methods for generating HDR-engineered CAR T cells rely on viral transduction or electroporation, approaches that limit global implementation and constrain patient access due to their cost, toxicity, and requirement for centralized manufacturing. Through a...

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Literature Corpus work
60a4694c-3012-5da0-b5af-a8c7d2d09ea4
DOI
10.64898/2026.08.04.741347
Open publication

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