Article

Harnessing extracellular vesicles for efficient siRNA delivery <i>in vitro</i> and <i>in vivo</i>

2023-08-27

Abstract excerpt

To fulfill the potential of small interference RNA (siRNA) therapeutics, diverse and efficient delivery platforms for siRNA are urgently needed. Extracellular vesicles (EVs) are endogenous, cell secreted nano-vehicles which have been explored for functional siRNA delivery, yet impurities in EVs preparation and lack of efficient siRNA loading method have been limiting its further development into clinical applicati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: df1105bf-7033-5c30-92bc-eeb2536c7050
DOI: 10.1101/2023.08.26.554924

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Harnessing extracellular vesicles for efficient siRNA delivery <i>in vitro</i> and <i>in vivo</i>DOI 10.1101/2023.08.26.554924Read

An exosome-based gene delivery platform for cell-specific CRISPR/Cas9 genome editingSemantic proximity Read

Quantitative Assessment of shRNA Loading and Delivery Efficiency of Engineered Extracellular VesiclesSemantic proximity Read

Therapeutic face of RNAi:<i>in vivo</i>challengesSemantic proximity Read

Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles.Semantic proximity Read

CRISPR delivery with extracellular vesicles: Promises and challengesSemantic proximity Read

Gene Editing by Extracellular Vesicles.Semantic proximity Read

Small extracellular vesicles (sEVs): discovery, functions, applications, detection methods and various engineered formsSemantic proximity Read

Clinical Translation of Extracellular VesiclesSemantic proximity Read

A comprehensive update of siRNA delivery design strategies for targeted and effective gene silencing in gene therapy and other applicationsSemantic proximity Read

Extracellular Vesicles as Mediators of Intercellular Communication: Implications for Drug Discovery and Targeted TherapiesSemantic proximity Read

Functionalized exosomes for targeted therapy in cancer and regenerative medicine: genetic, chemical, and physical modificationsSemantic proximity Read

Comparison of extruded cell nanovesicles and exosomes in their molecular cargos and regenerative potentialsSemantic proximity Read