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Mitochondrial sirtuins, key regulators of aging

8 Jun 2025

Abstract excerpt

Mitochondrial dysfunction is a hallmark of aging, characterized by a decline in mitochondrial biogenesis and quality control, compromised membrane integrity, elevated ROS production, damaged mitochondrial DNA (mtDNA), impaired mitochondrial-nuclear crosstalk, and deregulated metabolic balance. Among the key longevity regulators, sirtuin family members SIRT3, SIRT4, and SIRT5 are predominantly localized to...

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PMID: 40799515
DOI: 10.1093/lifemedi/lnaf019

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