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Article

SIRT1: new avenues of discovery for disorders of oxidative stress

10 Jan 2012

Abstract excerpt

INTRODUCTION: The sirtuin SIRT1 is expressed throughout the body, has broad biological effects and can significantly affect both cellular survival and longevity during acute and long-term injuries, which involve both oxidative stress and cell metabolism. AREAS COVERED: SIRT1 has an intricate role in the pathology, progression, and treatment of several disease entities, including neurodegenerative disorders such...

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PMID: 22233091
DOI: 10.1517/14728222.2012.648926

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