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SIRT1 and SIRT6: The role in aging-related diseases

25 Jul 2023

Abstract excerpt

Aging is characterized by progressive functional deterioration with increased risk of mortality. It is a complex biological process driven by a multitude of intertwined mechanisms such as increased DNA damage, chronic inflammation, and metabolic dysfunction. Sirtuins (SIRTs) are a family of NAD+-dependent enzymes that regulate fundamental biological functions from genomic stability and lifespan to energy...

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PMID: 37499928
DOI: 10.1016/j.bbadis.2023.166815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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