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A New Vision of Mitochondrial Unfolded Protein Response to the Sirtuin Family

24 Jan 2020

Abstract excerpt

Mitochondrial damage is involved in many pathophysiological processes, such as tumor development, metabolism, and neurodegenerative diseases. The mitochondrial unfolded protein response (mtUPR) is the first stress-protective response initiated by mitochondrial damage, and it repairs or clears misfolded proteins to alleviate this damage. Studies have confirmed that the sirtuin family is essential for the...

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PMID: 31976838
DOI: 10.2174/1570159x18666200123165002

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