Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines.

Oncotarget - 22 Sept 2015

Bai Huimin, Li Haixia, Li Weihua, Gui Ting, Yang Jiaxin, Cao Dongyan, Shen Keng

Abstract excerpt

OBJECTIVES: To explore the genetic and molecular events that control subclones exhibiting distinct invasive/migratory capacities derived from human epithelial ovarian cancer (EOC) cell line A2780 and SKOV3. METHODS: Single-cell subclones were isolated and established that were derived from the SKOV3 and A2780 cell lines through limiting dilution methodology. Transwell insert assays and MTT assays were performed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis Regulatory Proteins
Share to Carcinoma, Ovarian Epithelial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Nude

Share to Neoplasms, Glandular and Epithelial

Share to Phosphatidylinositol 3-Kinase

Share to Proto-Oncogene Proteins c-akt

Share to TOR Serine-Threonine Kinases

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 26267321
DOI: 10.18632/oncotarget.4550
PMCID: PMC4694849

Genes

AKT3
ECM1
PRKCB
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines.PMID 26267321Read ↗

Functional characterization of a panel of high-grade serous ovarian cancer cell lines as representative experimental models of the disease.Semantic proximity Read ↗

Autophagy Induction Results in Enhanced Anoikis Resistance in Models of Peritoneal DiseaseSemantic proximity Read ↗

Molecular characterization of 7 new established cell lines from high grade serous ovarian cancer.Semantic proximity Read ↗

Dualistic effects of PRKAR1A as A Potential Anticancer Target in Cancer Cells and Cancer-Derived Stem CellsSemantic proximity Read ↗

Ovulatory Follicular Fluid Facilitates the Full Transformation Process for the Development of High-Grade Serous CarcinomaSemantic proximity Read ↗

The importance of the PI3K/AKT/MTOR pathway in the progression of ovarian cancer.Semantic proximity Read ↗

Proteomic and Transcriptomic Profiling Identifies Mediators of Anchorage-Independent Growth and Roles of Inhibitor of Differentiation Proteins in Invasive Lobular Breast CancerSemantic proximity Read ↗

Pre-existing cancer cells and induced fibroblasts are key cells for early chemoresistance in ovarian cancerSemantic proximity Read ↗

Ovarian Cancer Cell Line Panel (OCCP): Clinical Importance of In Vitro Morphological SubtypesSemantic proximity Read ↗

PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway?Semantic proximity Read ↗

Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours.Semantic proximity Read ↗

Identification of anoikis-related tumor microenvironment characteristics and prognostic signature in ovarian cancer at bulk and single-cell levelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.