Article
PI3K in cancer: its structure, activation modes and role in shaping tumor microenvironment.
Future oncology (London, England) - 1 Mar 2018
Liu Xiaoyan, Xu Yan, Zhou Qing, Chen Minjiang, Zhang Yu, Liang Hongge, Zhao Jing, Zhong Wei, Wang Mengzhao
Abstract excerpt
The role of PI3K in cancer has been well established, and mutations of PIK3CA, the gene coding for catalytic subunit p110α of PI3K, are found in approximately 30% human cancers. The hyperactivated PI3K pathway plays a central role in the tumor cell activities such as proliferation, differentiation, chemotaxis, survival, trafficking and metabolism. Besides, PI3K pathway is involved in the regulation of...
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