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OmpF Downregulation Mediated by Sigma E or OmpR Activation Confers Cefalexin Resistance in <i>Escherichia coli</i> in the Absence of Acquired β-Lactamases

2021-05-17

Abstract excerpt

Cefalexin is a widely used 1 st generation cephalosporin, and resistance in Escherichia coli is caused by Extended-Spectrum (e.g. CTX-M) and AmpC β-lactamase production and therefore frequently coincides with 3 rd generation cephalosporin resistance. However, we have recently identified large numbers of E. coli isolates from human infections, and from cattle, where cefalexin resistance is not β-lactamase media...

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Literature Corpus work
d864303c-923c-529c-a634-dda63fd6cd50
DOI
10.1101/2021.05.16.444350
Open publication

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OmpF Downregulation Mediated by Sigma E or OmpR Activation Confers Cefalexin Resistance in <i>Escherichia coli</i> in the Absence of Acquired β-LactamasesDOI 10.1101/2021.05.16.444350
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