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Cefiderocol “under siege”? Understanding the rise of NDM-mediated resistance to novel agents

1 Jan 2025

Abstract excerpt

The global spread of antimicrobial resistance (AMR) underscores the critical need for the rapid development of new drugs. Particularly alarming is the surge in metallo-β-lactamases (MBLs) - broad spectrum enzymes able to inactivate penicillins, cephalosporins, and carbapenems. Cefiderocol (FDC), a siderophore-containing cephalosporin, was initially reported as resistant to MBL hydrolysis. Indeed, FDC has been...

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PMID: 40510314
DOI: 10.1039/d5sc02122g

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