Back to search

Article

Single point mutations in global regulatory genes restore cephalosporin resistance in a low-MIC <i>Enterococcus faecium</i> natural isolate

2025-08-25

Abstract excerpt

<h4>ABSTRACT</h4> Enterococcus faecium exhibits intrinsic resistance to cephalosporins (CPH), yet the genetic determinants of this phenotype remain incompletely understood. To date, E. faecium strains with low minimum inhibitory concentrations (MICs) to CPH have only been described following genetic manipulation. At Parc Taulí University Hospital, we identified a clinical isolate of ampicillin-susceptible E. fa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
eb8bb19e-352a-5674-a42b-215afd701b29
DOI
10.1101/2025.08.20.671320
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Single point mutations in global regulatory genes restore cephalosporin resistance in a low-MIC <i>Enterococcus faecium</i> natural isolateDOI 10.1101/2025.08.20.671320
Single point mutations in global regulatory genes restore cephalosporin resistance in a low-MIC Enterococcus faecium natural isolate.Semantic proximity
Heteroresistance in <i>Enterococcus faecalis</i> is prevalent for key antibiotics and mainly caused by mutationsSemantic proximity
Allele-Specific Effects of Mutations in the Rifampin Resistance-Determining Region (RRDR) of RpoB on Physiology and Antibiotic Resistance in <i>Enterococcus faecium</i>Semantic proximity
A high-resolution genomic and phenotypic analysis of resistance evolution of an<i>Escherichia coli</i>strain from a critical care patient treated with piperacillin/tazobactamSemantic proximity
Evolutionary trajectories of β-lactam resistance in <i>Enterococcus faecalis</i> strainsSemantic proximity
Aminoglycoside heteroresistance in <i>Enterobacter cloacae</i> is driven by the cell envelope stress responseSemantic proximity
OmpF Downregulation Mediated by Sigma E or OmpR Activation Confers Cefalexin Resistance in <i>Escherichia coli</i> in the Absence of Acquired β-LactamasesSemantic proximity
Piperacillin/tazobactam resistant, cephalosporin susceptible <i>Escherichia coli</i> bloodstream infections are driven by multiple acquisition of resistance across diverse sequence typesSemantic proximity
Co-diversification of Enterococcus faecium Core Genomes and PBP5: Evidences of pbp5 Horizontal TransferSemantic proximity
Genome-wide identification of ampicillin resistance determinants in Enterococcus faecium.Semantic proximity
Rising daptomycin resistance in <i>Enterococcus faecium</i> across a hospital system occurred via rampant recurrent evolution and occasional transmission between patientsSemantic proximity
Fitness determinants of vancomycin-resistant <i>Enterococcus faecium</i> during growth in human serumSemantic proximity
Select a neighboring publication to make it the new centre.