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Replicative senescence of neural progenitors induces astrocyte senescence in 2D cultures and human midbrain organoids

2026-06-19

Abstract excerpt

Astrocyte senescence (astrosenescence) has emerged as a potential mechanism through which ageing may progressively impair glial homeostatic neuronal support and render the brain more vulnerable to neurodegenerative diseases such as Parkinson’s disease (PD). Yet human experimental models that specifically recapitulate astrosenescence within a PD-relevant genetic background are lacking. Here, we applied passage-indu...

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Literature Corpus work
8c9826a0-0ec7-54fb-a1dc-164aa11d87d9
DOI
10.64898/2026.06.17.732317
Open publication

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Replicative senescence of neural progenitors induces astrocyte senescence in 2D cultures and human midbrain organoidsDOI 10.64898/2026.06.17.732317
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