Article

PD-L1 regulates inflammatory macrophage development from human pluripotent stem cells by maintaining interferon-gamma signal

2022-12-16

Abstract excerpt

PD-L1 (programmed death-ligand 1) serves as a pivotal immune checkpoint in both the innate and adaptive immune systems. PD-L1 is expressed in macrophages in response to interferon-gamma (IFNγ). We examined whether PD-L1 might regulate macrophage development. We established PD-L1 -/- human pluripotent stem cells, differentiated them into macrophages, and observed a 60% reduction of CD11B + CD45 + macrophages in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d848e802-975c-5a7e-a455-a8f15aba94ea
DOI: 10.1101/2022.12.14.520176

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PD-L1 regulates inflammatory macrophage development from human pluripotent stem cells by maintaining interferon-gamma signalDOI 10.1101/2022.12.14.520176Read

Large-scale generation of IL-12 secreting macrophages from human pluripotent stem cells for cancer therapySemantic proximity Read

Transcriptional profiling of macrophages derived from monocytes and iPS cells identifies a conserved response to LPS and novel alternative transcriptionSemantic proximity Read

Patient iPSC-Derived Macrophages to Study Inborn Errors of the IFN-γ Responsive Pathway.Semantic proximity Read

Production and Characterization of Human Macrophages from Pluripotent Stem Cells.Semantic proximity Read

Macrophages derived from human induced pluripotent stem cells (iPSCs) serve as a high-fidelity cellular model for investigating HIV-1, dengue, and influenza virusesSemantic proximity Read

Efficient, long term production of monocyte-derived macrophages from human pluripotent stem cells under partly-defined and fully-defined conditions.Semantic proximity Read

Functional analysis and transcriptomic profiling of iPSC-derived macrophages and their application in modeling Mendelian disease.Semantic proximity Read

Human Induced Pluripotent Stem Cell-Derived Macrophages Share Ontogeny with MYB-Independent Tissue-Resident Macrophages.Semantic proximity Read

Induced pluripotent stem cell-derived macrophages as a model for human inflammasome signalingSemantic proximity Read

Modeling tissue-resident macrophage development from mouse pluripotent stem cellsSemantic proximity Read

ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophagesSemantic proximity Read

Human Induced Pluripotent Stem Cell-Derived Macrophages for Unraveling Human Macrophage Biology.Semantic proximity Read