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ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages

24 Jul 2021

Abstract excerpt

Macrophages play crucial roles in many human disease processes. However, obtaining large numbers of primary cells for study is often difficult. We describe 2D and 3D methods for directing human induced pluripotent stem cells (hiPSCs) into macrophages (iMACs). iMACs generated in 2D culture showed functional similarities to human primary monocyte-derived M2-like macrophages, and could be successfully polarized into...

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PMID: 34311122
DOI: 10.1016/j.bone.2021.116129

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