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Large-scale generation of IL-12 secreting macrophages from human pluripotent stem cells for cancer therapy

2 Feb 2024

Abstract excerpt

Genetically engineered macrophages (GEMs) have emerged as an appealing strategy to treat cancers, but they are largely impeded by the cell availability and technical challenges in gene transfer. Here, we develop an efficient approach to generate large-scale macrophages from human induced pluripotent stem cells (hiPSCs). Starting with 1 T150 dish of 10 6 hiPSCs, more than 10 9 mature macrophages (iMacs) could be...

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PMID: 38390556
DOI: 10.1016/j.omtm.2024.101204

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