Article

Induced pluripotent stem cell-derived macrophages as a model for human inflammasome signaling

2025-09-10

Abstract excerpt

<h4>Summary</h4> Macrophage models are a mainstay of inflammasome research, however current human in vitro macrophage models have significant limitations. Here we generate induced pluripotent stem cell (iPSC)-derived macrophages (iMacs) to study inflammasome signaling and benchmark them with human monocyte-derived macrophages (HMDMs). We confirm that iMacs express high levels of macrophage markers and are highly...

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Literature Corpus work: 35f002f4-c965-574f-adb5-5951528179e3
DOI: 10.1101/2025.09.05.674456

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