Article
Differential nucleosome organization in human interphase and metaphase chromosomes
2025-11-12
Abstract excerpt
DNA bendability plays a critical role in stabilizing nucleosome assembly, yet its contribution to nucleosome dynamics in vivo remains poorly understood. Here, we applied chemical mapping to generate high-resolution nucleosome positioning maps at single-base-pair resolution from human interphase and metaphase chromosomes, revealing distinct patterns of nucleosome organization between the two states. Notably, we obs...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- e3ec9ca1-3bd9-5296-bec2-8c5cb49f2991
- DOI
- 10.1101/2025.11.11.687715