Article

Structure of Native Chromatin Fibres Revealed by Cryo-ET <i>in situ</i>

2023-09-05

Abstract excerpt

The structure of chromatin plays pivotal roles in regulating gene transcription, DNA replication and repair, and chromosome segregation. This structure, however, remains elusive. Using cryo-FIB and cryo-ET, we delineated the 3D architecture of native chromatin fibres in intact interphase human T-lymphoblasts and determined the in-situ structures of nucleosomes in different conformations. These chromatin fibres ar...

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Literature Corpus work: 76d00fd3-f495-5e2b-883d-4b7fab558e1a
DOI: 10.1101/2023.09.03.556082

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