Article

Generation of Infectious Prions Amenable to Site-specific Click Chemistry

2026-04-10

Abstract excerpt

Prion diseases are a group of fatal neurodegenerative diseases that proceed through the templated conversion of the normal PrP C protein to a self-propagating and infectious form, termed PrP Sc . This conversion process is central to disease progression. However, due to difficulties in producing functional PrP Sc molecules that can be selectively modified with chemical probes, many aspects of PrP Sc biology ca...

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Literature Corpus work: d83f6f11-9f44-5ecc-9c33-894fe1277b35
DOI: 10.64898/2026.04.08.717205

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