Article

Overexpression of Polycystin-2 alleviates acute lung injury in mice by activating autophagy

2024-01-31

Abstract excerpt

Polycystin-2(PC2) composed of PKD2 gene encoding a transmembrane protein plays an important role in kidney disease, but the role of which in lipopolysaccharide (LPS)-induced acute lung injury (ALI) was unclear. We overexpressed PC2 in lung epithelial cell in vitro and in vivo and examined the role of PC2 in inflammatory response induced by LPS in vitro and in vivo.We demonstrated that overexpression of PC2 signifi...

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Literature Corpus work: d837c698-035e-5295-ab56-b386e774f84b
DOI: 10.22541/au.170668548.85362699/v1

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