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Article

Canagliflozin alleviates LPS-induced acute lung injury by modulating alveolar macrophage polarization.

International immunopharmacology - 1 Nov 2020

Lin Fengyu, Song Chao, Zeng Yanjun, Li Yi, Li Haitao, Liu Ben, Dai Minhui, Pan Pinhua

Abstract excerpt

BACKGROUND: Canagliflozin (CANA), a sodium-glucose cotransporter 2 inhibitor, is a novel therapeutic agent that exhibits multiple actions in type 2 diabetes. CANA can regulate intracellular glucose metabolism and exert anti-inflammatory effects in immune cells. Alveolar macrophage polarization balance is often associated with lower inflammation in acute lung injury (ALI). However, little is known about the...

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PMID: 33182027
DOI: 10.1016/j.intimp.2020.106969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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