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A novel anti-acute lung injury mechanism of astilbin: inhibition of epithelial cells ferroptosis by targeting NRF2 activation via binding Val608 site of NRF2.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 30 Oct 2025

Fang Cheng, Pang Sainan, Chen Kegong, Wang Gang, Liu Qiaohan, Zhao Binger, Li Bo, Shi Bendong, Guo Yiyuan, Cai Jingzeng, Zhang Ziwei

Abstract excerpt

OBJECTIVE AND DESIGN: Astilbin (ATB) is a newly discovered natural compound with anti-inflammatory and immunomodulatory effects. However, its effects and underlying mechanisms in acute lung injury (ALI) remain unclear. MATERIAL OR SUBJECTS: An ALI model was established by intratracheal injection of lipopolysaccharide (LPS) into the trachea of C57BL/6 mice. In vitro, MLE-12 cells were stimulated with LPS. ATB was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41165829
DOI: 10.1007/s00011-025-02119-z

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GPX4

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