Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Macrophage TRIM21 knockout inhibits septic acute lung injury by downregulating autophagy regulator protein ubiquitination

13 Jun 2025

Abstract excerpt

Acute lung injury (ALI) caused by sepsis is a fatal disease characterized by an systemic inflammatory response to invading pathogens. Inducing macrophage macroautophagy/autophagy is a critical strategy to combat the inflammatory response in septic ALI. The E3 ubiquitin ligase TRIM21 plays important roles in autophagy. However, the mechanism connecting macrophage TRIM21-associated autophagy to ALI development...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Inflammasome and immune disorders
Share to Mosquito-borne diseases and control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40509575
DOI: 10.1080/15548627.2025.2519063

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Macrophage TRIM21 knockout inhibits septic acute lung injury by downregulating autophagy regulator protein ubiquitinationPMID 40509575Read ↗

TRIM36 Catalyzes K63-Linked Ubiquitination of TAK1 to Drive Septic InflammationSemantic proximity Read ↗

Review: the Role and Mechanisms of Macrophage Autophagy in SepsisSemantic proximity Read ↗

The Role of Protein Ubiquitination in the Onset and Progression of SepsisSemantic proximity Read ↗

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.Semantic proximity Read ↗

Mechanism of Mitophagy and Its Role in Sepsis Induced Organ Dysfunction: A ReviewSemantic proximity Read ↗

TRIM-directed selective autophagy regulates immune activation.Semantic proximity Read ↗

TFEB Dependent Autophagy-Lysosomal Pathway: An Emerging Pharmacological Target in SepsisSemantic proximity Read ↗

TRIM22 regulates macrophage autophagy and enhances Mycobacterium tuberculosis clearance by targeting the nuclear factor–multiplicity κB/beclin 1 pathwaySemantic proximity Read ↗

The Role of Autophagy in Sepsis: Protection and Injury to OrgansSemantic proximity Read ↗

Autophagy in sepsis-induced acute lung injury: Friend or foe?Semantic proximity Read ↗

Macrophage Notch1 drives septic cardiac dysfunction by impairing mitophagy and promoting NLRP3 activationSemantic proximity Read ↗

Malat1 regulates PMN-MDSC expansion and immunosuppression through p-STAT3 ubiquitination in sepsisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.