Article

Spatiotemporal proximity labeling tools to track GlcNAc sugar-modified functional protein hubs during cellular signaling

2022-04-13

Abstract excerpt

A fundamental mechanism that all eukaryotic cells use to adapt to their environment is dynamic protein modification with monosaccharide sugars. In humans, O-linked N-acetylglucosamine (O-GlcNAc) is rapidly added to and removed from diverse protein sites as a response to fluctuating nutrient levels, stressors, and signaling cues. Two aspects remain challenging for tracking functional O-GlcNAc events with chemical s...

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Literature Corpus work: 1ed06787-69fc-5f23-9390-237cbe263cc1
DOI: 10.1101/2022.04.13.488185

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