Article

Broken force dispersal network in tip-links by the mutations induces hearing-loss

2019-04-19

Abstract excerpt

Tip-link as force-sensor in the hearing conveys the mechanical force originating from sound to ion-channels while maintaining the integrity of the entire sensory assembly in inner-ear. This delicate balance between structure and function of tip-links is regulated by Ca 2+ -ions present in endolymph. Mutations at the Ca 2+ -binding sites of tip-links often lead to congenital deafness, sometimes syndromic defects...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d8153016-fddb-59f8-83b1-e255829e0305
DOI: 10.1101/614610

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Broken force dispersal network in tip-links by the mutations induces hearing-lossDOI 10.1101/614610Read

The Dynamic Strength of the Hair-Cell Tip Link Reveals Mechanisms of Hearing and DeafnessSemantic proximity Read

Single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection.Semantic proximity Read

Nanomechanics of wild-type and mutant dimers of the inner-ear tip-link protein protocadherin 15.Semantic proximity Read

Tip links in hair cells: molecular composition and role in hearing lossSemantic proximity Read

The mechanical cell – the role of force dependencies in synchronising protein interaction networksSemantic proximity Read

Weakening of interaction networks with aging in tip-link protein induces hearing loss.Semantic proximity Read

Regulation of PIEZO1 channel force sensitivity by interblade handshakingSemantic proximity Read

The tetraspan LHFPL5 is critical to establish maximal force sensitivity of the mechanotransduction channel of cochlear hair cells.Semantic proximity Read

Direct gating and mechanical integrity of Drosophila auditory transducers require TRPN1.Semantic proximity Read

Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearingSemantic proximity Read

TRIOBP promotes bidirectional radial stiffness gradients within the organ of CortiSemantic proximity Read

Calcium binds and rigidifies the dysferlin C2A domain in a tightly coupled manner.Semantic proximity Read