Article

Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing

2025-05-11

Abstract excerpt

Our sense of hearing relies upon speedy synaptic transmission of sound information from cochlear inner hair cells (IHCs) to spiral ganglion neurons (SGNs). To accomplish this, IHCs employ a sophisticated presynaptic machinery including the multi-C 2 -domain protein otoferlin which is affected by human deafness mutations. Otoferlin is essential for IHC-exocytosis but how it binds Ca 2+ and the target membrane to...

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Literature Corpus work: d71b8f1e-934b-59d0-861f-155780733dcd
DOI: 10.1101/2025.05.10.653085

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