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Article

Single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection.

Nature communications - 8 Feb 2021

Mulhall Eric M, Ward Andrew, Yang Darren, Koussa Mounir A, Corey David P, Wong Wesley P

Abstract excerpt

The conversion of auditory and vestibular stimuli into electrical signals is initiated by force transmitted to a mechanotransduction channel through the tip link, a double stranded protein filament held together by two adhesion bonds in the middle. Although thought to form a relatively static structure, the dynamics of the tip-link connection has not been measured. Here, we biophysically characterize the strength...

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Identifiers

PMID: 33558532
DOI: 10.1038/s41467-021-21033-6
PMCID: PMC7870652

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Single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection.PMID 33558532Read ↗

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