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Regulation of PIEZO1 channel force sensitivity by interblade handshaking

13 Jun 2025

Abstract excerpt

PIEZOs form trimeric calcium-permeable nonselective cationic channels that serve mechanical sensing needs across eukaryotic biology. Forces act on the channels by causing their curved blades to flatten and decompact, leading to an activated state, but it is unclear how this is regulated to enable the channels to adapt to different contexts. To identify potential mechanisms, we performed coarse-grained and...

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PMID: 40512861
DOI: 10.1126/sciadv.adt7046

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