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Article

Weakening of interaction networks with aging in tip-link protein induces hearing loss.

The Biochemical journal - 15 Jan 2021

Garg Surbhi, Sagar Amin, Singaraju Gayathri S, Dani Rahul, Bari Naimat K, Naganathan Athi N, Rakshit Sabyasachi

Abstract excerpt

Age-related hearing loss (ARHL) is a common condition in humans marking the gradual decrease in hearing with age. Perturbations in the tip-link protein cadherin-23 that absorbs the mechanical tension from sound and maintains the integrity of hearing is associated with ARHL. Here, in search of molecular origins for ARHL, we dissect the conformational behavior of cadherin-23 along with the mutant S47P that...

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Share to Cadherin Related Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33270084
DOI: 10.1042/BCJ20200799
PMCID: PMC7813477

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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