Article

Lateral opening site of human oligopeptide transporter 2 plays a key role in the interaction with polymyxins

2026-04-02

Abstract excerpt

<h4>Background</h4> Multidrug-resistant (MDR) Gram-negative bacteria have presented a critical global health crisis and polymyxins remain a last-line therapy. However, their clinical use has been largely limited by nephrotoxicity. Human oligopeptide transporter 2 (hPepT2) is a membrane transporter mediating the reabsorption of polymyxins in renal cells, contributing to their nephrotoxicity. However, it remains un...

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Literature Corpus work: d7f57c09-5d3a-5bb5-918b-07a771fdbc11
DOI: 10.64898/2026.04.01.715775

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