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Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins

22 Oct 2015

Abstract excerpt

OBJECTIVES: Polymyxins are a last-line therapy to treat MDR Gram-negative bacterial infections. Nephrotoxicity is the dose-limiting factor for polymyxins and recent studies demonstrated significant accumulation of polymyxins in renal tubular cells. However, little is known about the mechanism of polymyxin uptake into these cells. Oligopeptide transporter 2 (PEPT2) is a solute carrier transporter (SLC) expressed...

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PMID: 26494147
DOI: 10.1093/jac/dkv340

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