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A post-injury immune challenge with lipopolysaccharide following adult traumatic brain injury alters neuroinflammation and the gut microbiome acutely, but has little effect on chronic outcomes

2024-09-30

Abstract excerpt

<h4>ABSTRACT</h4> Patients with a traumatic brain injury (TBI) are susceptible to hospital-acquired infections, presenting a significant challenge to an already-compromised immune system. The consequences and mechanisms by which this dual insult worsens outcomes are poorly understood. This study aimed to explore how a systemic immune stimulus (lipopolysaccharide, LPS) influences outcomes following experimental TB...

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Literature Corpus work
0791ebd8-d5f9-50d2-8e87-69d1e8189c40
DOI
10.1101/2024.09.28.615631
Open publication

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A post-injury immune challenge with lipopolysaccharide following adult traumatic brain injury alters neuroinflammation and the gut microbiome acutely, but has little effect on chronic outcomesDOI 10.1101/2024.09.28.615631
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