Transcriptional activation of <i>Bmal1</i> drives the inflammatory activity of monocytes by modulating mitochondrial unfolded protein response during hypobaric hypoxic stress

Abstract excerpt

<h4>Background</h4> Hypoxic stress-induced inflammation had been considered to play an important role in the onset and progression of altitude-related illnesses, but the origin of inflammatory cytokines, the specific responding cell types, and molecular mechanisms remain unknown. Mitochondria are responsible for oxygen consumption and recently reported to be the master regulators of inflammation, but it is not cl...

Topics

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• Autophagy in Disease and Therapy
• Cancer, Hypoxia, and Metabolism
• Cytokine Signaling Pathways and Interactions
• Heme Oxygenase-1 and Carbon Monoxide
• High Altitude and Hypoxia
• Mitochondrial Function and Pathology
• Pregnancy and preeclampsia studies
• Spaceflight effects on biology

Identifiers and source

Literature Corpus work

90d8957d-b81f-5675-b6a5-b0e8239ae2b8

DOI

10.1101/2024.04.02.587843