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Article

A proteomics-based approach reveals the role of the activation of astrocytes with the A1 phenotype in medullary neuroinflammation after TBI in mice.

Neuroscience - 16 Apr 2026

Chen Zhijie, Li Mingming, Wang Henan, Sun Mengbei, Ma Jiaqi, Si Ting, Cheng Xinuo, Li Shanshan, Chen Guang, Xu Xiang

Abstract excerpt

Unclear mechanisms of secondary injury in the medulla oblongata (MO) after traumatic brain injury (TBI) prompted the exploration of the relationship between astrocyte phenotype changes in the MO and neuroinflammation after TBI, providing new insights into the pathogenesis of TBI. In this study, C57BL/6J mice were randomly divided into sham and closed-TBI groups. Pathophysiological changes after TBI were evaluated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41730499
DOI: 10.1016/j.neuroscience.2026.02.039

Genes

ADIPOR2
TNF
C3
GFAP
S100A10
UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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