Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deficiency in the voltage-gated proton channel Hv1 increases M2 polarization of microglia and attenuates brain damage from photothrombotic ischemic stroke.

Journal of neurochemistry - 1 Oct 2016

Tian Dai-Shi, Li Chun-Yu, Qin Chuan, Murugan Madhuvika, Wu Long-Jun, Liu Jun-Li

Abstract excerpt

Microglia become activated during cerebral ischemia and exert pro-inflammatory or anti-inflammatory role dependent of microglial polarization. NADPH oxidase (NOX)-dependent reactive oxygen species (ROS) production in microglia plays an important role in neuronal damage after ischemic stroke. Recently, NOX and ROS are consistently reported to participate in the microglial activation and polarization; NOX2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimetabolites
Share to Brain Infarction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bromodeoxyuridine

Share to Intracranial Thrombosis

Share to Microglia

Share to NADPH Oxidase 2

Share to NADPH Oxidases

Share to Primary Cell Culture

Source

Open in PubMed Open full text

Identifiers

PMID: 27470181
DOI: 10.1111/jnc.13751
PMCID: PMC5037018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deficiency in the voltage-gated proton channel Hv1 increases M2 polarization of microglia and attenuates brain damage from photothrombotic ischemic stroke.PMID 27470181Read ↗

Amyloid precursor protein is a subunit of microglial Hv1 channels.Semantic proximity Read ↗

Hv1 proton channel is essential for splenic antibacterial defense and immune homeostasis during the chronic phase of traumatic brain injury in male miceSemantic proximity Read ↗

Kir6.1/K-ATP channel modulates microglia phenotypes: implication in Parkinson's disease.Semantic proximity Read ↗

Selective modulation of microglia polarization to M2 phenotype for stroke treatment.Semantic proximity Read ↗

MitoQ attenuates brain damage by polarizing microglia towards the M2 phenotype through inhibition of the NLRP3 inflammasome after ICH.Semantic proximity Read ↗

The critical role of P2XR/PGC-1α signalling pathway in hypoxia-mediated pyroptosis and M1/M2 phenotypic differentiation of mouse microglia.Semantic proximity Read ↗

M1 Microglia Induced Neuronal Injury on Ischemic Stroke via Mitochondrial Crosstalk between Microglia and Neurons.Semantic proximity Read ↗

Kv1.3 channel blockade alleviates cerebral ischemia/reperfusion injury by reshaping M1/M2 phenotypes and compromising the activation of NLRP3 inflammasome in microglia.Semantic proximity Read ↗

Treatment targets for M2 microglia polarization in ischemic stroke.Semantic proximity Read ↗

Activation of Swell1 in microglia suppresses neuroinflammation and reduces brain damage in ischemic strokeSemantic proximity Read ↗

Kv1.3 blockade alleviates white matter injury through reshaping M1/M2 phenotypes after intracerebral hemorrhageSemantic proximity Read ↗

Deficiency of Hv1 Proton Channel Enhances Macrophage Antigen Presentation and Anti-Tumor Responses in GliomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.