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Integrative analysis of TCGA transcriptomic states and DepMap dependencies prioritizes candidate vulnerabilities in immune-cold microsatellite-stable colorectal cancer

2026-07-06

Abstract excerpt

Microsatellite-stable/microsatellite instability-low colorectal cancer (MSS/MSI-L CRC) is generally resistant to immune checkpoint blockade, but the biological states underlying this resistance are heterogeneous. We integrated TCGA COAD/READ patient transcriptomic profiles, MSIsensor-based MSS/MSI-L classification, curated immune and stromal module scoring, focused differential expression and DepMap CRISPR depende...

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Literature Corpus work
5d34ff62-0cb7-57f1-a348-67e5684e5c0c
DOI
10.64898/2026.07.04.736484
Open publication

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Integrative analysis of TCGA transcriptomic states and DepMap dependencies prioritizes candidate vulnerabilities in immune-cold microsatellite-stable colorectal cancerDOI 10.64898/2026.07.04.736484
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