Article

Hypoxia-induced metastatic heterogeneity in pancreatic cancer

2025-10-01

Abstract excerpt

<title>Abstract</title> <p>In most solid tumors, hypoxia is a critical physical attribute that reprograms malignant cells into a highly metastatic state. Specifically, hypoxia is a well-established inducer of cellular plasticity, which is associated with treatment resistance and metastasis. Furthermore, hypoxia exacerbates chromosomal instability (CIN), a hallmark of cancer that can be initiated by the loss of Tr...

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Literature Corpus work: 5d574e99-4909-5b87-b9ee-9d9fdfdcf3bd
DOI: 10.21203/rs.3.rs-7394295/v1

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