Article

Type-1 interferon-driven innate and <i>GZMK</i> + CD8 T cell activation precedes subclinical joint inflammation when rheumatoid arthritis is imminent

2026-03-30

Abstract excerpt

Rheumatoid arthritis is a prototypical autoimmune disease, characterised by prolonged systemic autoimmunity prior to organ-specific tissue inflammation. To achieve the contemporary goal of autoimmune disease prevention, a nuanced understanding of the transition from systemic autoimmunity to tissue-specific inflammation is critical. Here, we sought to identify immune signatures associated with the transition to sub...

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Literature Corpus work: d7e5653e-4499-50ca-b003-13f67e26cb5f
DOI: 10.64898/2026.03.27.26349561

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Type-1 interferon-driven innate and <i>GZMK</i> + CD8 T cell activation precedes subclinical joint inflammation when rheumatoid arthritis is imminentDOI 10.64898/2026.03.27.26349561Read

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