ACPA-negative rheumatoid arthritis: From immune mechanisms to clinical translation

Abstract excerpt

The presence of anti-citrullinated protein autoantibodies (ACPA) is a hallmark feature of rheumatoid arthritis (RA), which causes chronic joint destruction and systemic inflammation. Based on ACPA status, RA patients can be sub-grouped into two major subsets: ACPA-positive RA (ACPA + RA) and ACPA-negative RA (ACPA – RA). Accumulating evidence have suggested that ACPA + RA and ACPA – RA are two distinct disease...

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