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Integrated multi‑omics defines immune programmes underlying progression to rheumatoid arthritis in anti-citrullinated protein antibody positive individuals with arthralgia and palindromic rheumatism.

2026-03-24

Abstract excerpt

<title>Abstract</title> <p>Rheumatoid arthritis (RA) develops through a prolonged preclinical phase in which systemic immune dysregulation precedes joint inflammation. To clarify the molecular programmes driving divergent outcomes in anti-citrullinated protein antibody (ACPA) positive individuals, we performed integrated multi‑omics profiling of 192 ACPA+ at‑risk individuals, including those with arthralgia and p...

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Literature Corpus work
45916ee2-513c-5e9c-9106-8e7e672e8349
DOI
10.21203/rs.3.rs-9108192/v1
Open publication

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Integrated multi‑omics defines immune programmes underlying progression to rheumatoid arthritis in anti-citrullinated protein antibody positive individuals with arthralgia and palindromic rheumatism.DOI 10.21203/rs.3.rs-9108192/v1
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