Article
Type I Interferons in Autoimmunity: Implications in Clinical Phenotypes and Treatment Response.
The Journal of rheumatology - 1 Sept 2023
Londe Ana Carolina, Fernandez-Ruiz Ruth, Julio Paulo Rogério, Appenzeller Simone, Niewold Timothy B
Abstract excerpt
Type I interferon (IFN-I) is thought to play a role in many systemic autoimmune diseases. IFN-I pathway activation is associated with pathogenic features, including the presence of autoantibodies and clinical phenotypes such as more severe disease with increased disease activity and damage. We will review the role and potential drivers of IFN-I dysregulation in 5 prototypic autoimmune diseases: systemic lupus...
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