Article

Nanopore microscope identifies RNA isoforms with structural colors

2021-10-16

Abstract excerpt

Identifying RNA transcript isoforms requires intricate protocols that suffer from various enzymatic biases. Here we design three-dimensional molecular constructs that enable identification of transcript isoforms at the single-molecule level using solid-state nanopore microscopy. We refold target RNA into RNA identifiers (IDs) with designed sets of complementary DNA strands. Each reshaped molecule carries a unique...

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Literature Corpus work: 345e5b55-75a2-5011-8db4-3948f7c45bb6
DOI: 10.1101/2021.10.16.464631

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