Nanopore sequencing to detect A-to-I editing sites.

Abstract excerpt

Adenosine-to-inosine (A-to-I) RNA editing, mediated by the ADAR family of enzymes, is pervasive in metazoans and functions as an important mechanism to diversify the proteome and control gene expression. Over the years, there have been multiple efforts to comprehensively map the editing landscape in different organisms and in different disease states. As inosine (I) is recognized largely as guanosine (G) by...

Topics

• Inosine
• RNA Editing
• Nanopore Sequencing
• Adenosine
• Humans
• Animals
• Sequence Analysis, RNA
• Polymorphism, Single Nucleotide