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Reduced expression of COVID-19 host receptor,<i>ACE2</i>is associated with small bowel inflammation, more severe disease, and response to anti-TNF therapy in Crohn’s disease

2020-04-23

Abstract excerpt

Angiotensin-Converting Enzyme 2 ( ACE2 ) has been identified as the host receptor for SARS-coronavirus 2 (SARS-CoV-2) which has infected millions world-wide and likely caused hundreds of thousands of deaths. Utilizing transcriptomic data from four cohorts taken from Crohn’s disease (CD) and non-inflammatory bowel disease (IBD) subjects, we observed evidence of increased ACE2 mRNA in ileum with demographic features...

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Identifiers and source

Literature Corpus work
5a8f6752-b016-502c-94b9-5ec11c6c65af
DOI
10.1101/2020.04.19.20070995
Open publication

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