Article

Reduced SARS-CoV-2 infection levels and pathotype specific altered antiviral transcriptional response in IBD intestinal organoids

2025-11-26

Abstract excerpt

<title>Abstract</title> <p> Background IBD is characterized by altered immune reactions and infections are thought to trigger chronic inflammation in IBD. The gut represents a productive reservoir for SARS-CoV-2 and the aforementioned factors together with immunosuppression used to treat IBD are likely influencing the outcomes of IBD patients with COVID-19. Methods We used large and small intestinal organoids fr...

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Literature Corpus work: f03983ee-1a4d-5c3e-9ca8-2736b2883a97
DOI: 10.21203/rs.3.rs-8029502/v1

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