Article

Heterotypic interfacial tension between oncogenic and wild-type populations forms the mechanical basis of tissue-specific oncogenesis in epithelia

2025-03-16

Abstract excerpt

Why does the same oncogenic mutation drive tumor formation in some tissues but not in others? While cancer driver mutations are well-documented, their tissue-specific effects remain largely attributed to genetic factors, leaving the biophysical aspects underexplored. Here, we demonstrate that mechanical interactions, specifically interfacial tension between newly transformed and wildtype epithelial cells are criti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 68b7ae89-89f2-5a32-979e-9486465d060f
DOI: 10.1101/2025.03.14.643229

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Heterotypic interfacial tension between oncogenic and wild-type populations forms the mechanical basis of tissue-specific oncogenesis in epitheliaDOI 10.1101/2025.03.14.643229Read

Heterotypic interfacial tension between oncogenic and wild-type populations forms the mechanical basis of tissue-specific oncogenesis in epithelia.Semantic proximity Read

Oncogenic RAS instructs morphological transformation of human epithelia via differential tissue mechanicsSemantic proximity Read

Matrix mechanics regulates epithelial defence against cancer by tuning dynamic localization of filamin.Semantic proximity Read

Bridging the Gap in Cancer Cell Behavior Against Matrix Stiffening: Insights from a Trizonal ModelSemantic proximity Read

Linking changes in epithelial morphogenesis to cancer mutations using computational modeling.Semantic proximity Read

Biophysical perspectives to understanding cancer-associated fibroblastsSemantic proximity Read

Generation of anisotropic strain dysregulates wild-type cell division at the interface between host and oncogenic tissueSemantic proximity Read

Border forces and friction control epithelial closure dynamics.Semantic proximity Read

Mechanotransduction of strain regulates an invasive phenotype in newly transformed epithelial cellsSemantic proximity Read

A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticitySemantic proximity Read

Regulation of micropatterned curvature-dependent FA heterogeneity on cytoskeleton tension and nuclear DNA synthesis of malignant breast cancer cellsSemantic proximity Read

Systems-Level Properties of EGFR-RAS-ERK Signaling Amplify Local Signals to Generate Dynamic Gene Expression HeterogeneitySemantic proximity Read