Article

Persistent epigenetic signals propel a senescence-associated secretory phenotype and trained innate immunity in CD34+ hematopoietic stem cells from diabetic patients

2023-12-20

Abstract excerpt

<h4>Background: </h4> Diabetes-induced trained immunity contributes to the development of atherosclerosis and its complications. This study aimed to investigate in humans whether epigenetic signals involved in immune cell activation and inflammation are initiated in hematopoietic stem/progenitor cells (HSPCs) and transferred to differentiated progeny. Methods and results High glucose (HG)-exposure of cord blood (...

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Literature Corpus work: d7c66ea3-84b7-5fd6-97c5-8de8d13a0cb5
DOI: 10.21203/rs.3.rs-3769111/v1

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Persistent epigenetic signals propel a senescence-associated secretory phenotype and trained innate immunity in CD34+ hematopoietic stem cells from diabetic patientsDOI 10.21203/rs.3.rs-3769111/v1Read

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