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Article

Epigenetic changes in bone marrow progenitor cells influence the inflammatory phenotype and alter wound healing in type 2 diabetes.

Diabetes - 1 Apr 2015

Gallagher Katherine A, Joshi Amrita, Carson William F, Schaller Matthew, Allen Ronald, Mukerjee Sumanta, Kittan Nico, Feldman Eva L, Henke Peter K, Hogaboam Cory, Burant Charles F, Kunkel Steven L

Abstract excerpt

Classically activated (M1) macrophages are known to play a role in the development of chronic inflammation associated with impaired wound healing in type 2 diabetes (T2D); however, the mechanism responsible for the dominant proinflammatory (M1) macrophage phenotype in T2D wounds is unknown. Since epigenetic enzymes can direct macrophage phenotypes, we assessed the role of histone methylation in bone marrow (BM)...

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Share to Bone Marrow Cells
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

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Share to Interleukin-12

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Share to Stem Cells

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Source

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Identifiers

PMID: 25368099
DOI: 10.2337/db14-0872
PMCID: PMC4375075

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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