Article
Short-term sustained hyperglycaemia fosters an archetypal senescence-associated secretory phenotype in endothelial cells and macrophages.
Redox biology - 1 May 2018
Prattichizzo Francesco, De Nigris Valeria, Mancuso Elettra, Spiga Rosangela, Giuliani Angelica, Matacchione Giulia, Lazzarini Raffaella, Marcheselli Fiorella, Recchioni Rina, Testa Roberto, La Sala Lucia, Rippo Maria Rita, Procopio Antonio Domenico, Olivieri Fabiola, Ceriello Antonio
Abstract excerpt
Diabetic status is characterized by chronic low-grade inflammation and an increased burden of senescent cells. Recently, the senescence-associated secretory phenotype (SASP) has been suggested as a possible source of inflammatory factors in obesity-induced type 2 diabetes. However, while senescence is a known consequence of hyperglycaemia, evidences of SASP as a result of the glycaemic insult are missing. In...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.